I’ve mentioned it but have yet to really describe it here on this blog: Delta Sleep-Inducing Peptide (DSIP), a neuropeptide first discovered in rabbits. It is a longer peptide than epitalon: Тrр-Аlа-Gly-Gly-Asp-Ala-Ser-Gly-Glu
It is suspected to have a low half-life due to amino peptidases that cleave after the Trp. However, that is really only one amino acid in so it may still serve a purpose in the body after this cleavage. It is claimed to have influences on cortisol levels, prolactin, and the activity of N-acetyl transferase (possibly involved in conversion of serotonin to NAS?).
I had been using DSIP from a certain source previously but I have it from a new source now that has described the sequence as Trp-Ala-Gly-Gly-Asp-Ala-Ser(PO3H2)-Gly-Glu. The serine is phosphorylated. There has been some suggestion that phospho-DSIP is more potent for sleep purposes [Kimura & Inoue, 1989]...and also less potent...[Tsunashima, et al., 1990].
A couple weeks ago I bought a TON of Phospho-DSIP thinking that with a greater potency, I could take less of it. Last night I broke open the first container and took the dosage I would normally take for DSIP (~1mg) by subcutaneous injection (on accident, my injector missed the vein) and intranasally. No improvement of sleep was observed at all. This could be due to the epitalon having potentially lasting effects. I plan on continuing to try Phospho-DSIP for the next few days to account for that.
Unfortunately, I strongly suspect I am going to take a heavy loss on this one. We’ll see - I am still holding out hope that it isn’t true.
More information on DSIP to come as I feel like (mostly: have time) writing about it...
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